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To prevent contamination, each dropper is for one individual, do not share among patients. If oral dose is given once daily or every other day, administer in the morning to coincide with the body's normal cortisol secretion. For the treatment of atopic dermatitis or eczema, bullous dermatitis herpetiformis, contact dermatitis, cutaneous T-cell lymphoma or mycosis fungoides, exfoliative dermatitis, pemphigus, severe psoriasis, severe seborrheic dermatitis, and severe erythema multiforme.
Administration of corticosteroids to pediatric patients should be limited to the least amount compatible with an effective therapeutic regimen. Pediatric patients may be more susceptible to developing systemic toxicity; adrenal suppression and increased intracranial pressure have been reported with the use and/or withdrawal of various corticosteroid formulations in young patients. Further, children receiving corticosteroids are immunosuppressed, and are therefore more susceptible to infection. Normally innocuous infections can become fatal in these children, and care should be taken to avoid exposure to these diseases. Published studies provide evidence of efficacy and safety in pediatric patients for the treatment of nephrotic syndrome , and aggressive lymphomas and leukemias . Use prednisolone with caution in patients with glaucoma; corticosteroids can elevate intraocular pressure with possible damage to the optic nerves.
Following biopsy to confirm diagnosis, corticosteroids are usually instituted soon afterward. Corticosteroid use is an adjunctive measure; removal of the suspected offending agent /cause is the primary treatment. While many case reports suggest a possible net benefit to the use of corticosteroids for AIN, some experts advocate for more prospective study of their value.
These effects are less likely to occur with the synthetic derivatives except when used in large doses. Dietary salt restriction and potassium supplementation may be necessary. Dosage of PRELONE (prednisolone ) ' Syrup should be individualized according to the severity of the disease and the response of the patient. For pediatric patients, the recommended dosage should be governed by the same considerations rather than strict adherence to the ratio indicated by age or body weight. Existing emotional instability or psychosis may be aggravated by corticosteroids. Psychiatric derangements may appear when corticosteroids are used, ranging from euphoria, insomnia, mood swings, personality changes, and severe depression, to frank psychosis.
Dosage must be individualized and is variable depending on the nature and severity of the disease, and on patient response. Infants born of mothers who have received substantial doses of corticosteroids during pregnancy should be carefully observed for signs of hypoadrenalism. Infants born of mothers who have received substantial doses of corticosteroid during pregnancy should be carefully observed for signs of hypoadrenalism. The most important physical property of an oral corticosteroid for children is that doses be easily swallowed and retained.
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